Pancreatic cancer, BRCA and genetic testing

 Several years ago, I got my genome sequenced at 30-50x coverage. The proximate incentive was that Veritas offered this service for $200, and for an additional $100, I got my variant call file, so I now know the variants for each of my genes, relative to the reference genome.


Ultimately, I was motivated by my dad's diagnosis of Frontotemporal Dementia, and wanted to know whether I have any of the known risk variants for that condition (I don't). I've also checked my status for risk variants for hypercholesterolemia, hypertension, and various cancers.

Some folks don't want their genome sequenced because they believe there's nothing they can do about their genome. My feelings are mirrored in this quote:

"As strange as this sounds, knowing I have a BRCA mutation actually makes me feel empowered and I am grateful. With my strong family history of cancer, I always assumed I would get cancer too. Now, I'm not just waiting for bad news: I know my risk and can decide what I want to do with this information, rather than just hoping to be lucky."

Knowledge is power.

https://www.medpagetoday.com/opinion/second-opinions/101475?xid=nl_mpt_Genetics_update_2022-11-03&eun=g1700464d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Automated%20Specialty%20Update%20Genetics%202022-11-03&utm_term=NL_Gen_Int_SurveySlideshows_Genetics

Comments

Post a Comment

Popular posts from this blog

Two sides

Image
  Yes, there are two sides to every question. In most cases, there is a correct side and a wrong side. In the case of Kamala Harris, the correct side is that she was born a US citizen. The wrong side is that her parents had to be citizens or permanent residents for her to be a citizen. President Trump pretended to be unsure about this, just as he pretended for five years that Barack Obama is not a citizen. In the case of the Harris noncitizen claim, it is backed by the racist C laremont Institute: "The Claremont Institute masquerades as an intellectual salon of the right, but it is really just a racist fever swamp with deep connections to the conspiratorial alt-right. It even granted a fellowship to Jack Posobiec, who helped promote the notorious Pizzagate conspiracy theory. Claremont’s resident bigots offer deranged fantasies of violently expelling Americans from their home country because of their ethnic backgrounds. Their work deserves the intellectual weight given to that of D
Read more

Is Joe Biden too old?

The current meme about Joe Biden is that he's too old. Well, yes, he is old. But he seems to be functioning as an active president just fine. And the only other choice at this point is the GOP candidate for the Democratic nomination, RFK Jr. Before we throw away the incumbent advantage, we need to have a strong alternative. There is none. Trump is old, too. He's only three years younger, which is statistically insignificant. And while Joe walks or bikes, Trump rides a golf cart. Joe is trim, Trump is obese. And Trump has over 90 indictments, while after >40 years in elective office, Joe has none. Trump will be spending much of the GOP campaign season in court, although the Trumpenproletariat will still make him the nominee. Joe will fight this election based on his vision for the future. Trump will fight the election based on his vision for revenge for 2020. I'll be thinking of my child and grandchild. YMMV.
Read more

My 9/11 memorial

Today, several folks have posted 9/11 remembrances on FB. I’m fine with that. We should remember the people who died as a result of the plane crashes, as well as their families and friends. But don’t stop there. Also remember how this tragedy was cynically exploited for political purposes by folks like Rudy Giuliani and George Bush. How it was dishonestly used to justify the US invasion and military occupation of Iraq*, the torture and abuse of innocent Afghanis, and the continued incarceration without trials of men at the US military base in Guantanamo. Americans are rightly outraged by the 9/11 terrorism. But we should also be outraged at the atrocities committed by America in the name of the victims of 9/11. We should work to make sure another 9/11 never happens, and we should work to make sure our emotions are never again hijacked for political and financial profit. *15 of the 19 hijackers were from Saudi Arabia, a US ally. Zero were from Iraq. Thousands of Americans were killed o
Read more